Endocrine Abstracts

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Obesity, insulin resistance and hyperandrogenemia are features of PCOS and potentially affect lipid metabolism. On the other hand, obesity has an important influence on the lipid metabolism.Objectives: The aim of this stud...

Background: Thyroid autoantibodies cross blood-follicle barrier in titer dependent manner and may change oocyte microenvironment with adverse effects on implantation or post-implantation period. Thyroid autoimmunity (TAI) interfers with pregnancy course and newborn anthropometry in pregnancy achieved by assisted reproduction (ART).Objective: To light upon pregnancy course outcomes and newborn anthropometric characteristics regarding TAI in ART programme....

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

Background: Ketoconazole is a synthetic antifungal drug, and powerful inhibitor of steroidogenesis. Oral ketoconazole blocks both ovarian and adrenal androgen biosynthesis, and glucocorticoid synthesis, leading to a reduction in circulating testosterone and cortisol levels. In subjects with an intact HPA axis, ketoconazole by decreasing cortisol levels leads to compensatory rise an ACTH level.Objectives: To assess influence ketoconasole induced changes i...

In supine subjects aldosterone daily variations are determined by spontaneous PRA rhythmicity and ACTH secretory bursts. The aim of this study was to analyze diurnal and pulsatile aldosterone secretion in two patients with primary aldosteronism (PA): a 33-year-old woman with aldosterone producing adenoma (APA) and a 40-year-old woman with idiopathic adrenal hyperplasia (IAH). Blood samples were taken hourly during 24 hours at the time of the diagnosis and three months later, a...

In this study we wanted to assess whether affective changes influence cortisol response during low dose (1 microgram) ACTH test. Beck Inventory of Depression and Hamilton Anxiety Rating Scale and low dose ACTH test were performed in five subjects during the prolonged psychological stress induced by war and 18 months later. After the war, Beck Inventory of Depression and Hamilton Anxiety Rating Scale scores were significantly reduced. Suppression of the HPA axis was present dur...

Background: Although it is well known that glucocorticosteroids induce insulin resistance, probably due to postreceptor defects, the exact time scale is still a matter of debate.Objective: The aim of the present study was to determine the time scale of effects of therapeutic doses of glucocorticoids on insulin sensitivity.Methods: Study group consisted of 20 patients with Graves ophtalmopathy who were treated with corticosteroids f...

It is supposed a simillar dirnal change of TSH, free fatty acids (FFA) and leptin in humans. Hypothalamic-pituitary-thyroid axis (HPT) is suppressed during food deprivation while there is an elevation of FFA further influencing glucose metabolism. The aim of our study was to investigate whether leptin can act as a metabolic signal linking the adipose tissue metabolism and the HPT. We studied 13 women with polycystic ovary disease-PCOS (mean age: 26.6±1.83 years; BMI: 34...

Adrenal incidentalomas are referred as clinically silent adrenal masses discovered incidentally during diagnostic testing or treatment for conditions not related to suspicion of adrenal disease. Certain percent of them are hormonally active and autonomous cortisol secretion is reported with increasing frequency. The aim of the study was to assess value of 1mg-DST in subclinical Cushing’s syndrome (CS) compared to the other forms of adrenal incidentalomas. We have evaluate...